Nanoemulsion delivery system of tea polyphenols enhanced the bioavailability of catechins in rats
 
作者: 文章来源: 点击数: 更新日期:2017-11-02

Title


Nanoemulsion delivery system of tea polyphenols enhanced the bioavailability of catechins in rats


Authors


Yunru Peng, Qilu Meng, Jie Zhou, Bo Chen, Junjun Xi, Piaopiao Long, Liang Zhang*, Ruyan Hou*


Journal


Food Chemistry 242 (2018) 527–532.


Abstract


Tea polyphenols (TP) were emulsified with corn oil and polysorbate 80 by high-pressure homogenization. The oil in water (O/W) TP nanoemulsion had droplet sizes of 99.42 ± 1.25 nm after preparation. The TP nanoemulsion was stable during storage at 4, 25 or 40 °C for 20 days. An in vitro simulated digestion assay showed that the bioaccessibility of (−)-epigallocatechin gallate (EGCG) was increased in the nanoemulsion compared to that in aqueous solution, but that the bioaccessibilities of (−)-epigallocatechin (EGC), (−)-epicatechin (EC) and (−)-gallocatechin gallate (GCG) were greatly decreased. Compared with rats fed an aqueous TP solution, rats fed the TP nanoemulsion had significantly lower maximum plasma concentrations (Cmax) of EGCG and EGC, but the area under the plasma concentration-time curve (AUC0–t) was increased. The data show that use of a nanoemulsion system to deliver tea polyphenols may enhance the absorption of EGCG through controlled release.




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  • nanoemulsion delivery system of tea polyphenols enhanced the bioavailability of catechins in rats(彭韵如,张梁,侯如燕,2017).pdf
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