Address: School of Tea and Food Science, Anhui Agricultural University, West Changjiang Road, Hefei, 230036, Anhui, P. R. China

Professional Title: PhD, Professor

Telephone: (86)551 65786401

Fax: (86)551 65786765

Email: baoguanhu@ahau.edu.cn

 

Brief Biography

AHAU, B.S, 1996

China Pharmaceutical University, M.S, 1999

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PhD, 2002

 

Research Interests

Natural products isolation and identification

Drug discovery through natural products approach

Tea biochemistry and biotechnology

Ngal small molecule ligands searching

 

Professional Activities

2002.7-2004.7, working as assistant researcher in Natural Medicine Chemistry Laboratory of Shanghai Institute of Materia Medica, during which engaging in postdoctoral research in Novartis of Switzerland headquarters

2004.7-2008.7, engaging in postdoctoral research in Cancer Institute of Arizona State University USA; working in the Southwest natural products research center of Arizona University USA; doing postdoctoral research concerning natural products chemistry in Columbia University College of Physicians and Surgeons

2008.8-2011.6, working as associate research scientist in Columbia University College of Physicians and Surgeons

2011.7-present, teaching and doing researches concerning natural products development and utilization in AHAU

 

Academic Teaching

Development and Utilization of Natural Product Chemistry (Graduate Course)

Natural Medicine Research Progress (Graduate Course)

 

Patents:

 

1         Ling T.J.Wan, X.C.; Bao, G.H.; Zhang, L.; Luo,Z.M. et al.一种名为茯砖素B的儿茶素类衍生物及其制备方法和应用;申请号:201310060914.2;申请日:2013227日;公开号:CN103113384A

2         胡丰林, 鲍官虎, 陆瑞利, 刘肖肖: 具有抑制酪氨酸酶活性和清除自由基活性的拟青霉提取物及其用途. 安徽农业大学 March 26, 2014: CN201310582413.0

3         Barasch, Jonathan; Deng, Shixian; Bao, Guanhu; Landry, Donald W.   Lipocalin NGAL-binding mammalian siderophores and use thereof to treat iron deficiency and iron overload and lipocalin detection.    PCT Int. Appl.  (2010),     128pp.  CODEN: PIXXD2  WO  2010033847  A1  20100325  CAN 152:398219  AN 2010:384442    CAPLUS

4         Liang, Jingyu; Wu, Feihua; Bao, Guanhu; Cheng, Qilei.   Plant extract for preventing and treating diabetes, its formulation and pharmaceutical use.    Faming Zhuanli Shenqing Gongkai Shuomingshu  (2004),     12 pp.  CODEN: CNXXEV  CN  1488344  A  20040414  CAN 142:341854  AN 2004:1100087    CAPLUS

5         Liang, Jingyu; Wu, Feihua; Bao, Guanhu; Cheng, Qilei.   A natural compound useful for treating diabetes, its preparation and use.    PCT Int. Appl.  (2004), 26 pp.  CODEN: PIXXD2  WO  2004039759  A1  20040513  CAN 140:395497  AN 2004:390207    CAPLUS

 

Journals:

 

1.         Guan-Hu Bao*, Jonathan Barasch, Jie Xu, Wei Wang, Feng-Lin Hu, Shi-Xian Deng. Purification and structural characterization of “simple catechol”, the NGAL-Siderochelin siderophore in human urine RSC Advances 2015, 5(36), 28527-28535.

2.         Wen-Jun Zheng, Xiao-Chun Wan, Guan-Hu Bao*. Brick dark tea: a review of the manufacture, chemical constituents and bioconversion of the major chemical components during fermentation. Phytochemistry Reviews 2015,14(3): 499-523.

3.         Yue, Y., Chu, G.X., Liu, X.S., Tang, X., Wang, W., Liu, G.J., Yang, T., Ling, T.J., Wang, X.G, Zhang, Z.Z., Xia, T., Wan, X.C, Bao, G.H*. (2014). TMDB: A literature-curated database for small molecular compounds found from tea. BMC Plant Biology, 14: 243.

4.         Yun-Fei Zhu, Jing-Jing Chen, Xiao-Ming Ji, Xin Hu, Tie-Jun Ling, Zheng-Zhu Zhang, Guan-Hu Bao*, Xiao-Chun Wan*. Changes of major tea polyphenols and production of four new B-ring fission metabolites of catechins from post-fermented Jing-Wei Fu brick tea. Food Chemistry, 2015, 170: 110-117.

5.         Bao, G.H. *; Xu, J.; Hu, F.L.; Wan X.C.; Deng, S.X.; Barasch J. EGCG inhibit chemical reactivity of iron through forming an Ngal-EGCG-iron complex. BioMetals, 2013, 26(6),1041-1050.

6.         Lu, R.L.; Luo, F.F.; Hu, F.L.*; Huang, B.; Li, C.R.; Bao, G.H.* Identification and production of a novel natural pigment, Cordycepoid A, from Cordyceps bifusispora Appl. Microbiol. Biotechnol. 2013, 97(14), 6241-6249.

7.         George R. Pettit, Rui Tan, Guan-Hu Bao, Noeleen Melody, Dennis L. Doubek, Song Gao, Jean-Charles Chapuis, and Lee Williams,  Antineoplastic Agents. 587. Isolation and Structure of 3-Epipancratistatin from Narcissus cv. Ice FolliesJournal of Natural Products, 2012, 75 (4), 771-773.

8.         Bao, Guanhu; Clifton, Matthew; Hoette, Trisha M; Mori, Kiyoshi; Deng, Shi-Xian; Qiu, Andong; Viltard, Melanie; Williams, David; Paragas, Neal; Leete, Thomas; Kulkarni,Ritwij; Li, Xiangpo; Lee, Belinda; Kalandadze, Avtandil; Ratner1, Adam J; Pizarro,Juan Carlos; Schmidt-Ott, Kai M; Landry, Donald W; Raymond, Kenneth N; Strong, Roland K; Barasch, Jonathan. Iron Traffics in Circulation Bound to Siderocalin (Ngal) in Complex with a Bacterial Metabolite Called Catechol, Nature Chemical Biology, 2010; 6(8): 602-609.

 

Project

China National Science Foundation 81170654/H0507

Anhui Agricultural University Talents Foundation (YJ2011-06)

Anhui Outstanding Youth Science Foundation 1108085J04

 


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