Address: School of Tea and Food Science, Anhui Agricultural University, West Changjiang Road, Hefei, 230036, Anhui, P. R. China
Professional Title: PhD, Professor
Telephone: (86)551 65786283
Fax: (86)551 65786283
Anhui Agriculture University, B.S, 1985
Anhui Agriculture University, M.S, 1988
Institute of Solid State Physics, PhD, 2004
Nutrition and Toxicology
Tea and Health
Selenium and Health
1988.9-1999.7 Hefei Institute of Economy and Technology, China
1999.8-2000.2 University of Science and Technology, China
2000.3-2002.2 Institute of Food Research, UK
2002.3-2009.2 University of Science and Technology, China
2009.3-present AHAU, China
Honors and Achievements
National Excellent Teacher
The 3rd Chinese Outstanding Youth Science and technology Innovation Award
The invention of preparation technology of Nano-Se with reduced risk of Selenium toxicity (China’s patent ZL97107038.5)
The invention of Sodium selenosulfate at an innocuous dose preventing cisplatin-induced gastrointestinal toxicity(US patent 8,480,995 B2, China’s patentZL200710023256.4)
The foundation of using Selenium for the prevention of growth of cancer cells in the peritoneal cavity
The proposal of coordination between Selenium and other foods’ functional components
The editor of 3 works concerning Toxicology which was invited by FDA experts
The critics of several SCI journals including Chemical Reviews
1. Zhang L, Wu S, Wang D, Wan X, Zhang J (corresponding author, *). Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. In: Sahu SC, Casciano D (eds) Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. John Wiley & Sons, pp 131-144, 2014.
2. Wang X, Sun K, Tan Y, Wu S, Zhang J*. Efficacy and safety of selenium nanoparticles administered intraperitoneally for the prevention of growth of cancer cells in the peritoneal cavity. Free Radic Biol Med. 72C:1-10, 2014.
3. Sun K, Eriksson SE, Tan Y, Zhang L, Arnér ES, Zhang J*. Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury. Biochim Biophys Acta. 1840:2105-2111, 2014.
4. Zhang L, Wei Y, Zhang J*. Novel mechanisms of anticancer activities of green tea component epigallocatechin-3-gallate. Anticancer Agents Med Chem. 14:779-786, 2014.
5. Wu S, Sun K, Wang X, Wang D, Wan X, Zhang J*. Protonation of epigallocatechin-3-gallate (EGCG) results in massive aggregation and reduced oral bioavailability of EGCG-dispersed selenium nanoparticles. J Agric Food Chem. 61:7268-7275. 2013.
6. Sun K, Wu S, Wang Y, Wan X, Thompson HJ, Zhang J*. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem Toxicol. 52:36–41, 2013.
7. Huang J, Zhang Y, Zhou Y, Zhang Z, Xie Z, Zhang J, Wan X. Green tea polyphenols alleviate obesity in broiler chickens through the regulation of lipid-metabolism-related genes and transcription factor expression. J Agric Food Chem. 61:8565-8572, 2013.
8. Wang Y, Lu H, Wang D, Li S, Sun K, Wan X, Taylor EW, Zhang J*. Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase. Toxicol Appl Pharmacol. 265:342-350, 2012.
9. Wang D, Taylor EW, Wang Y, Wan X, Zhang J*. Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. Int J Nanomedicine. 7:1711–1721, 2012.
10. Li J, Sun K, Ni L, Wang X, Wang D, Zhang J*. Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity. Toxicol Appl Pharmacol. 258:376-383, 2012.
11. Zhang J*, Taylor EW, Wan X, Peng D*. Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. Int J Nanomedicine. 7:815–825, 2012.
12. Zhang L, Zhang Z, Lu Y, Zhang J, Preedy VR. L-theanine from green tea: Transport and effects on health. In: Preedy VR (ed) Tea in Health and Disease Prevention. Academic Press, pp 425-435, 2012.
13. Zhang J*, Spallholz J. Toxicity of selenium compounds and nano-selenium particles. In: Casciano D, Sahu SC (eds) Handbook of Systems Toxicology. John Wiley & Sons. pp 787-802, 2011.
14. Lu Y, Zhang J, Wan X, Long M, Li D, Lei P, Zhang Z. Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion. Food Chem. 125:277-280, 2011.
15. Li S, Zhang J*, Li J, Chen D, Matteucci M, Curd J, Duan J. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol Trace Elem Res. 136:294-301, 2010.
16. Zhang J*. Biological properties of red elemental selenium at nano size (Nano-Se) in vitro and in vivo. In: Sahu SC, Casciano D (eds) Nanotoxicity: From In Vivo and In Vitro Model to Health Risks. John Wiley & Sons. pp 97-114, 2009.
17. Wang X, Zhang J*, Xu T. Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level. Eur J Heart Failure. 11:154-162, 2009.
18. Zhang J*, Wang X, Xu T. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol Sci. 101:22-31, 2008.
19. Zhang J*, Peng D, Lu H, Liu Q. Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite. Toxicol Appl Pharmacol. 226:251-259, 2008.
20. Zhang J*, Wang X, Lu H. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127-136, 2008.
21. Wang X, Zhang J*, Xu T. Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy. Eur J Pharmacol. 579:66-73, 2008.
22. Zhang J*, Wang H, Peng D, Taylor EW. Further insight into the impact of sodium selenite on selenoenzymes: High-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol Lett. 176:223-229, 2008.
23. Zhang J*, Lu H, Wang X. Sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2 and three kinds of leukemia cells. Biol Trace Elem Res. 125:13-21, 2008.
24. Li H, Zhang J, Wang T, Luo W, Zhou Q, Jiang G. Elemental selenium particles at nano size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite. Aquat Toxicol 89:251-256, 2008.
25. Wang H, Zhang J*, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic Biol Med. 42:1524-1533, 2007.
26. Zhang J*, Lu H. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity. Free Radic Biol Med. 43:1574-1583, 2007.
27. Wang X, Zhang J*, Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol Appl Pharmacol. 218:88-95, 2007.
28. Zhang J*, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol Appl Pharmacol. 224:81-88, 2007.
29. Peng D, Zhang J*, Liu Q, Taylor EW. Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J Inorg Biochem. 101:1457-1463, 2007.
30. Peng D, Zhang J*, Liu Q. Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo. Biol Trace Elem Res. 117:77-88, 2007.
31. Zhang J*, Ma K, Wang H. Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase. Chem Biol Interact. 162:24-30, 2006.
32. Zhang J*, Wang H, Yan X, Zhang L. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76:1099-1109, 2005.
33. Zhang J*, Wang H, BaoY, Zhang L. Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci. 75:237-244, 2004.
34. Huang B, Zhang J (co-first author), Hou J, Chen C. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic. Biol Med. 35:805-813, 2003.
35. Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis. 24:497-503, 2003.
36. Gao X, Zhang J, Zhang L. Hollow sphere selenium nanoparticles: their in-vitro anti hydroxyl radical effect. Adv Mater. 14:290-293, 2002.
37. Zhang J, Gao X, Zhang L, Bao Y. Biological effects of a nano red elemental selenium. Biofactors. 15:27-38, 2001.